Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | HTR2C | P28335 | 3/20 | 0.66 |
| ▸ | HTR7 | P34969 | 3/20 | 0.66 |
| ▸ | HTR6 | P50406 | 3/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9869610 | 0.99 | HTR2A (0.67) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL228454 | 0.99 | HTR2A (0.70) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9396999 | 0.95 | HTR2A (0.69) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL27737572 | 0.92 | HTR2A (0.65) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9229261 | 0.89 | HTR2A (0.72) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL10577348 | 0.88 | HTR2A (0.71) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL10712477 | 0.88 | HTR2A (0.71) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16481601 | 0.86 | HTR2A (0.71) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14318600 | 0.86 | HTR2A (0.81) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4981971 | 0.85 | HTR2A (0.67) | HTR2AKDM4ECYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377528-B1 | Piperidines, process for their preparation and pharmaceutical compounds containing them | LIPHA (FR) | 1993-12-08 | — | — | EP | disclosed |
| US-5001134-A | Piperidines, processes of preparation and medications containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1991-03-19 | — | — | US | disclosed |
| EP-0377528-A1 | Piperidines, process for their preparation and pharmaceutical compounds containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1990-07-11 | — | — | EP | disclosed |