Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9230346 | 1.00 | HTR2B (0.41) | HTR2BMAOAGRM2MAPK1L3MBTL1 | |
| SCHEMBL8659488 | 0.82 | HTR2B (0.37) | HTR2B | |
| SCHEMBL14168007 | 0.82 | HTR2B (0.46) | HTR2BGRM2MAPK1L3MBTL1 | |
| SCHEMBL7911772 | 0.81 | HTR2B (0.50) | HTR2BMAOAGRM2MAPK1L3MBTL1 | |
| SCHEMBL15247384 | 0.80 | PTPN1 (0.37) | GRM2MAPK1L3MBTL1 | |
| SCHEMBL4921609 | 0.80 | CYP2D6 (0.47) | HTR2BGRM2MAPK1 | |
| SCHEMBL4953038 | 0.80 | CYP2D6 (0.47) | HTR2BGRM2MAPK1 | |
| SCHEMBL14168364 | 0.80 | MAOA (0.38) | MAOAGRM2MAPK1L3MBTL1 | |
| SCHEMBL10151437 | 0.80 | MAOA (0.38) | MAOAGRM2MAPK1L3MBTL1 | |
| SCHEMBL14173675 | 0.78 | HTR2B (0.40) | HTR2BMAOAGRM2MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647634-A1 | Method of preparing a heterocyclic intermediate for the production of optically active aryloxy-substituted vicinal aminoalcohols | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1995-04-12 | — | — | EP | disclosed |
| EP-0647633-A1 | Method of preparing a heterocyclic intermediate for the production of optically active aryloxysubstituted vicinal aminoalcohols | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1995-04-12 | — | — | EP | disclosed |
| EP-0153746-B1 | 3-AMINO-2-HYDROXYPROPYL DERIVATIVES OF PYRIMIDIN-4-ONE | MERCK & CO. INC. (US) | 1990-11-22 | — | — | EP | disclosed |
| US-4602093-A | ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1986-07-22 | — | — | US | disclosed |
| US-4598149-A | ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1986-07-01 | — | — | US | disclosed |
| EP-0153746-A2 | 3-Amino-2-hydroxypropyl derivatives of pyrimidin-4-one | MERCK & CO. INC. (US) | 1985-09-04 | — | — | EP | disclosed |