Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.45 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.44 |
| ▸ | F11 | P03951 | 4/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9230680 | 1.00 | TYK2 (0.45) | TYK2ACVRL1F11KLKB1PRSS1 | |
| SCHEMBL1553681 | 0.84 | SMARCA2 (0.49) | TYK2ACVRL1F11KLKB1PRSS1 | |
| SCHEMBL1553679 | 0.84 | SMARCA2 (0.49) | TYK2ACVRL1F11KLKB1PRSS1 | |
| SCHEMBL9229123 | 0.84 | ACVRL1 (0.51) | TYK2ACVRL1JAK2JAK1CDK9 | |
| SCHEMBL9229125 | 0.84 | ACVRL1 (0.51) | TYK2ACVRL1JAK2JAK1CDK9 | |
| SCHEMBL1552890 | 0.83 | ABL1 (0.49) | TYK2ACVRL1F11KLKB1PRSS1 | |
| SCHEMBL1552889 | 0.83 | ABL1 (0.49) | TYK2ACVRL1F11KLKB1PRSS1 | |
| SCHEMBL9231780 | 0.82 | ACVRL1 (0.54) | TYK2ACVRL1JAK2JAK1CDK9 | |
| SCHEMBL9231785 | 0.82 | ACVRL1 (0.54) | TYK2ACVRL1JAK2JAK1CDK9 | |
| SCHEMBL9234289 | 0.81 | TYK2 (0.59) | TYK2ACVRL1JAK2JAK1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5478838-A | Treating hypertension, angina pectoris, asthma, improving peripheral circulation | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| EP-0641781-A1 | 4-AMINO(ALKYL)CYCLOHEXANE-1-CARBOXAMIDE COMPOUND AND USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1995-03-08 | — | — | EP | disclosed |