Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.69 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.57 |
| ▸ | CASR | P41180 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22398944 | 0.89 | HTR7 (0.71) | HTR7FFAR1CASRDRD2DRD4 | |
| SCHEMBL10287112 | 0.88 | HTR7 (0.66) | HTR7FFAR1CASRDRD2DRD4 | |
| SCHEMBL12881923 | 0.86 | HTR7 (0.71) | HTR7FFAR1CASRDRD2DRD4 | |
| SCHEMBL9225987 | 0.85 | CYP1A1 (0.65) | HTR7FFAR1CASR | |
| SCHEMBL9756294 | 0.85 | HTR7 (0.52) | HTR7FFAR1 | |
| SCHEMBL6721718 | 0.85 | HTR7 (0.52) | HTR7FFAR1 | |
| SCHEMBL9226730 | 0.84 | HTR7 (0.51) | HTR7FFAR1 | |
| SCHEMBL10512694 | 0.84 | HTR7 (0.57) | HTR7FFAR1CASRDRD2DRD4 | |
| SCHEMBL9229536 | 0.83 | PTGER1 (0.60) | HTR7FFAR1DRD2HTR1A | |
| SCHEMBL3670702 | 0.82 | FFAR1 (0.76) | HTR7FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5382600-A | 3,3-diphenylpropylamines and pharmaceutical compositions thereof | PHARMACIA AKTIEBOLAG (SE) | 1995-01-17 | — | — | US | disclosed |
| EP-0325571-B1 | NEW AMINES, THEIR USE AND PREPARATION | Kabi Pharmacia AB (SE) | 1991-08-07 | — | — | EP | disclosed |
| EP-0325571-A1 | New amines, their use and preparation | Kabi Pharmacia AB (SE) | 1989-07-26 | — | — | EP | disclosed |