Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 18/20 | 0.93 |
| ▸ | FKBP4 | Q02790 | 2/20 | 0.93 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.93 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.93 |
| ▸ | MLNR | O43193 | 1/20 | 0.93 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.93 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.93 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.93 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.93 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.93 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.93 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.93 |
| ▸ | HTR2A | P28223 | 1/20 | 0.93 |
| ▸ | HTR2B | P41595 | 1/20 | 0.93 |
| ▸ | MTOR | P42345 | 1/20 | 0.93 |
| ▸ | FKBP1B | P68106 | 1/20 | 0.93 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.93 |
| ▸ | PPP3CA | Q08209 | 1/20 | 0.93 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.93 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21778810 | 1.00 | FKBP1A (0.93) | FKBP1AFKBP4ABCB11ADORA3MLNR | |
| SCHEMBL8365690 | 1.00 | FKBP1A (0.93) | FKBP1AFKBP4ABCB11ADORA3MLNR | |
| SCHEMBL9230760 | 1.00 | FKBP1A (0.93) | FKBP1AFKBP4ABCB11ADORA3MLNR | |
| SCHEMBL19757405 | 1.00 | FKBP1A (0.93) | FKBP1AFKBP4ABCB11ADORA3MLNR | |
| SCHEMBL19202681 | 1.00 | FKBP1A (0.93) | FKBP1AFKBP4ABCB11ADORA3MLNR | |
| SCHEMBL31554977 | 1.00 | FKBP1A (0.93) | FKBP1AFKBP4ABCB11ADORA3MLNR | |
| SCHEMBL18852680 | 1.00 | FKBP1A (0.93) | FKBP1AFKBP4ABCB11ADORA3MLNR | |
| SCHEMBL6427833 | 1.00 | FKBP1A (0.93) | FKBP1AFKBP4ABCB11ADORA3MLNR | |
| Tacrolimus Anhydrous SCHEMBL23565408 | 0.97 | FKBP1A (1.00) | FKBP1AFKBP4ABCB11ADORA3MLNR | |
| Tacrolimus Anhydrous SCHEMBL20932174 | 0.97 | FKBP1A (1.00) | FKBP1AFKBP4ABCB11ADORA3MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475994-B1 | MACROLIDES FOR THE TREATMENT OF REVERSIBLE OBSTRUCTIVE AIRWAYS DISEASES | FISONS PLC (GB) | 1994-09-14 | — | — | EP | claimed |
| EP-0346427-B1 | MACROCYCLIC COMPOUNDS | FISONS PLC (GB) | 1995-03-29 | — | — | EP | disclosed |