SCHEMBL9230936

SCHEMBL9230936

COC(=O)/C=C\C(=O)OCCNC(=O)CCc1cc(-n2nc3ccccc3n2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.47
▸ MEN1 O00255 2/20 0.47
▸ GAA P10253 5/20 0.45
▸ MAOB P27338 3/20 0.45
▸ MAOA P21397 2/20 0.45
▸ ACHE P22303 2/20 0.45
▸ LMNA P02545 2/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ AGTR1 P30556 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ GSK3B P49841 2/20 0.37
▸ KDM4E B2RXH2 2/20 0.35
▸ CYP1A2 P05177 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ BCHE P06276 1/20 0.33
▸ ALOX5 P09917 1/20 0.32
▸ POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10394998 1.00 KMT2A (0.47) KMT2AMEN1GAAMAOBMAOA
SCHEMBL9226822 0.91 KMT2A (0.48) KMT2AMEN1GAAMAOBMAOA
SCHEMBL9225045 0.86 KMT2A (0.47) KMT2AMEN1GAAMAOBMAOA
SCHEMBL14157763 0.84 KMT2A (0.50) KMT2AMEN1GAAMAOBMAOA
SCHEMBL8160946 0.84 KMT2A (0.55) KMT2AMEN1GAAMAOBMAOA
SCHEMBL9326704 0.83 KMT2A (0.54) KMT2AMEN1GAAMAOBMAOA
SCHEMBL13871632 0.82 KMT2A (0.50) KMT2AMEN1GAAMAOBMAOA
Hydrochloric Acid SCHEMBL15399357 0.82 KMT2A (0.53) KMT2AMEN1GAAMAOBMAOA
SCHEMBL9879519 0.82 KMT2A (0.53) KMT2AMEN1GAAMAOBMAOA
SCHEMBL9230761 0.82 GAA (0.43) KMT2AMEN1GAAMAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5476882-A Containing 2,2,6,6-tetraalkylpiperidine derivative CIBA-GEIGY CORPORATION (US) 1995-12-19 — — US disclosed
EP-0296391-B1 LIGHT-STABILIZED POLYMER MICROPARTICLES CONTAINING EPOXY GROUPS CIBA-GEIGY AG (CH) 1993-07-07 — — EP disclosed
EP-0226538-B1 LIGHT STABILIZED POLYMER MICROPARTICLES Ciba SC Holding AG (CH) 1991-09-11 — — EP disclosed
US-4894399-A Light-stabilized polymer microparticles containing epoxy groups CIBA-GEIGY CORPORATION (US) 1990-01-16 — — US disclosed
US-4892915-A Copolymers of 2-(2-hydroxy-5-acryloyloxyalkyl)phenyl-2H-benzotriazoles CIBA-GEIGY CORPORATION (US) 1990-01-09 — — US disclosed
EP-0296391-A2 Light-stabilized polymer microparticles containing epoxy groups CIBA-GEIGY AG (CH) 1988-12-28 — — EP disclosed
US-4785063-A LIGHT STABILIZERS CIBA-GEIGY CORPORATION (US) 1988-11-15 — — US disclosed
EP-0226538-A2 Light stabilized polymer microparticles CIBA-GEIGY AG (CH) 1987-06-24 — — EP disclosed
EP-0133164-A2 Compounds which can be copolymerised CIBA-GEIGY AG (CH) 1985-02-13 — — EP disclosed
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