SCHEMBL9236142

SCHEMBL9236142

O=Cc1nc[c]n1C(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8390054 0.69 ATM (0.35) CYP11B1CYP11B2
SCHEMBL584685 0.68 CYP11B1 (0.40) CYP11B1CYP11B2
SCHEMBL1735233 0.67 CYP11B1 (0.32) CYP11B1CYP11B2
SCHEMBL8140925 0.67 ALDH1A1 (0.40) CYP11B1CYP11B2
SCHEMBL9571803 0.65 ALDH1A1 (0.31) CYP11B1CYP11B2
SCHEMBL5326782 0.62 BRD4 (0.32) CYP11B1CYP11B2
SCHEMBL3849472 0.62 CYP11B1 (0.31) CYP11B1CYP11B2
SCHEMBL13447358 0.62 CYP11B1 (0.31) CYP11B1CYP11B2
SCHEMBL7478574 0.61 ALDH1A1 (0.39)
SCHEMBL5322803 0.61 CYP11B1 (0.36) CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0675112-A1 Imidazole-containing inhibitors of farnesyl protein transferase BRISTOL-MYERS SQUIBB COMPANY (US) 1995-10-04 EP disclosed