Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15614500 | 0.86 | KMT2A (0.47) | MAPK8MAPK9MAPK10POLBKMT2A | |
| SCHEMBL14720965 | 0.83 | KMT2A (0.51) | MAPK8MAPK9MAPK10POLBKMT2A | |
| SCHEMBL15203323 | 0.83 | KMT2A (0.51) | MAPK8MAPK9MAPK10POLBKMT2A | |
| SCHEMBL8629005 | 0.81 | KMT2A (0.46) | MAPK8MAPK9MAPK10POLBKMT2A | |
| SCHEMBL30687394 | 0.78 | MAPK8 (0.50) | MAPK8MAPK9MAPK10KMT2AL3MBTL1 | |
| SCHEMBL3053745 | 0.75 | PKM (0.67) | MAPK8MAPK9MAPK10KMT2AL3MBTL1 | |
| SCHEMBL5239795 | 0.74 | MAPK8 (0.51) | MAPK8MAPK9MAPK10POLBKMT2A | |
| SCHEMBL3280235 | 0.74 | KMT2A (0.76) | MAPK8MAPK9MAPK10KMT2AL3MBTL1 | |
| SCHEMBL5078857 | 0.74 | TSHR (0.55) | MAPK8MAPK9MAPK10KMT2AL3MBTL1 | |
| SCHEMBL13469238 | 0.74 | PKM (0.50) | MAPK8MAPK9MAPK10POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5418250-A | Hypotensive | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-23 | — | — | US | disclosed |
| US-5185351-A | Hypotensive agents; for treatment of congestive heart failure, renal failure and glaucoma | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-09 | — | — | US | disclosed |