Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.64 |
| ▸ | KCNJ1 | P48048 | 9/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9234853 | 0.85 | HRH3 (0.68) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL5151630 | 0.84 | KCNJ1 (0.70) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL9234850 | 0.83 | HRH3 (0.59) | HRH3KCNJ1KCNH2SIGMAR1 | |
| SCHEMBL9661978 | 0.82 | HRH3 (0.68) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL3156895 | 0.79 | HRH3 (1.00) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL5653299 | 0.79 | HRH3 (0.93) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL9235499 | 0.79 | KCNJ1 (0.66) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL9235807 | 0.78 | HRH3 (0.61) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL3156570 | 0.78 | HRH3 (0.97) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL914324 | 0.78 | HRH3 (0.97) | HRH3KCNJ1KCNH2MAOASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649838-A1 | N-phenylalkyl/phenoxyalkyl-azetidine/pyrrozidinel piperidine/hexahydroazepine derivatives as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-04-26 | — | — | EP | disclosed |