Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.68 |
| ▸ | KCNJ1 | P48048 | 11/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1546206 | 0.85 | DRD4 (0.63) | SIGMAR1 | |
| SCHEMBL1546203 | 0.85 | DRD4 (0.63) | SIGMAR1 | |
| SCHEMBL9234853 | 0.84 | HRH3 (0.68) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL9237409 | 0.82 | HRH3 (0.64) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL3156895 | 0.81 | HRH3 (1.00) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL5653299 | 0.81 | HRH3 (0.93) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL9660648 | 0.81 | LTA4H (0.65) | HRH3KCNH2SIGMAR1 | |
| SCHEMBL20909098 | 0.81 | BCHE (0.59) | SIGMAR1 | |
| SCHEMBL9235807 | 0.80 | HRH3 (0.61) | HRH3KCNJ1KCNH2MAOASIGMAR1 | |
| SCHEMBL3156570 | 0.80 | HRH3 (0.97) | HRH3KCNJ1KCNH2MAOASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307121-B1 | SULPHONAMIDE ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1992-03-18 | — | — | EP | disclosed |
| EP-0307121-A1 | Sulphonamide antiarrhythmic agents | Pfizer Limited (GB) | 1989-03-15 | — | — | EP | disclosed |