Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HNF4A | P41235 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924171 | 0.85 | HSD17B10 (0.42) | ALDH1A1NPC1HPGDRAB9AKMT2A | |
| SCHEMBL925293 | 0.76 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2NPSR1ATMKMT2A | |
| SCHEMBL925273 | 0.76 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2NPSR1ATMHPGD | |
| SCHEMBL924486 | 0.75 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2NPSR1ATMHPGD | |
| SCHEMBL925284 | 0.73 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2NPSR1ATMNPC1 | |
| SCHEMBL925968 | 0.73 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2NPSR1ATMHPGD | |
| SCHEMBL924612 | 0.72 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2NPSR1ATMHPGD | |
| SCHEMBL924151 | 0.72 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2NPSR1ATMNPC1 | |
| SCHEMBL26000144 | 0.72 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2NPSR1ATMNPC1 | |
| SCHEMBL31401053 | 0.71 | HPGD (0.50) | ALDH1A1SMN1; SMN2NPSR1ATMCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163766-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20110118250-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-19 | — | — | US | disclosed |
| US-7872009-B2 | Beta-Secretase modulators and methods of use | AMGEN INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-20070185103-A1 | Beta-secretase modulators and methods of use | AMGEN INC. | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118250-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | BACE1, BACE2, APP | ALDH1A1 2087/4885SMN1; SMN2 1434/4885NPSR1 1471/4885 |
| US-20070185103-A1 | Beta-secretase modulators and methods of use | BACE1, BACE2, APP | ALDH1A1 2087/4885SMN1; SMN2 1434/4885NPSR1 1471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.