Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TACR1 | P25103 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303719 | 0.84 | KMT2A (0.55) | MEN1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL20465941 | 0.81 | KMT2A (0.52) | MEN1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL17513637 | 0.81 | KMT2A (0.52) | MEN1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL20453813 | 0.81 | KMT2A (0.52) | MEN1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL10520185 | 0.80 | HRH4 (0.54) | MEN1MAPTKMT2ALMNACHRNB2 | |
| SCHEMBL15571714 | 0.79 | HPGD (0.72) | MEN1MAPTKMT2ATACR1HPGD | |
| SCHEMBL404391 | 0.79 | MEN1 (0.69) | MEN1MAPTKMT2AHPGDLMNA | |
| SCHEMBL1284855 | 0.78 | KMT2A (0.59) | MEN1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL27548891 | 0.78 | KMT2A (0.59) | MEN1MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL13073769 | 0.78 | KMT2A (0.59) | MEN1MAPTKMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995011880-A1 | SUBSTITUTED AMIDES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-05-04 | — | — | WO | disclosed |