Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CPA1 | P15085 | 3/20 | 0.50 |
| ▸ | CPB1 | P15086 | 1/20 | 0.50 |
| ▸ | CPA3 | P15088 | 1/20 | 0.50 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10519718 | 0.91 | HRH4 (0.52) | HRH4KMT2AMEN1MAPTCPA1 | |
| SCHEMBL7291238 | 0.91 | HRH4 (0.52) | HRH4KMT2AMEN1MAPTCPA1 | |
| SCHEMBL10520925 | 0.84 | KMT2A (0.57) | HRH4KMT2AMEN1LMNA | |
| SCHEMBL7291021 | 0.84 | KMT2A (0.57) | HRH4KMT2AMEN1LMNA | |
| SCHEMBL10519727 | 0.82 | HRH4 (0.54) | HRH4KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL10749706 | 0.82 | MME (0.49) | HRH4CPA1 | |
| SCHEMBL7352579 | 0.81 | CYP1A2 (0.65) | HRH4KMT2AMEN1CPA1CPB1 | |
| SCHEMBL10519520 | 0.80 | MMP8 (0.61) | HRH4KMT2AMEN1MAPTCHRNB2 | |
| SCHEMBL9238006 | 0.80 | MEN1 (0.57) | KMT2AMEN1MAPTLMNACHRNB2 | |
| SCHEMBL7288450 | 0.79 | EPHX1 (0.47) | HRH4KMT2AMEN1CPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4863904-A | Dipeptides as renin inhibitors | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0181110-A2 | Histidine derivatives as renin inhibitors | Kissei Pharmaceutical Co. Ltd. (JP) | 1986-05-14 | — | — | EP | disclosed |