Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9237758 | 0.85 | SMN1; SMN2 (0.50) | DPP7MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL16026613 | 0.81 | DPP7 (0.81) | DPP7GAASIGMAR1CCR3HTT | |
| Hydrochloric Acid SCHEMBL9236126 | 0.80 | DPP7 (0.70) | DPP7L3MBTL1BCHESIGMAR1CCR3 | |
| Hydrochloric Acid SCHEMBL1314603 | 0.79 | BCHE (0.69) | DPP7L3MBTL1BCHEACHEMAOB | |
| Bicarbonate SCHEMBL9234912 | 0.79 | POLB (0.52) | L3MBTL1HTTSMN1; SMN2KDM4EALDH1A1 | |
| Bicarbonate SCHEMBL9233396 | 0.79 | HTT (0.48) | SIGMAR1HTTSMN1; SMN2KDM4EALDH1A1 | |
| Bicarbonate SCHEMBL9239312 | 0.77 | HTT (0.49) | SIGMAR1HTTSMN1; SMN2KDM4EALDH1A1 | |
| Bicarbonate SCHEMBL9235058 | 0.77 | HTT (0.49) | SIGMAR1HTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1317607 | 0.77 | BCHE (0.70) | DPP7L3MBTL1BCHEACHEMAOB | |
| SCHEMBL8478310 | 0.75 | GPR119 (0.57) | BCHEACHEMAOBKDM4ECHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638553-A1 | Carboxylic acid amides having a terminal carboxylic acid group as aggregation inhibiting drugs | Dr. Karl Thomae GmbH (DE) | 1995-02-15 | — | — | EP | disclosed |