Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.69 |
| ▸ | HTR2A | P28223 | 11/20 | 0.69 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD1 | P21728 | 4/20 | 0.42 |
| ▸ | DRD5 | P21918 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8873552 | 0.90 | HTR2C (0.57) | HTR2CHTR2ADRD2DRD1DRD5 | |
| Fumaric Acid SCHEMBL8873545 | 0.90 | HTR2C (0.57) | HTR2CHTR2ADRD2DRD1DRD5 | |
| SCHEMBL8875204 | 0.89 | HTR2C (0.55) | HTR2CHTR2ADRD2DRD1DRD5 | |
| SCHEMBL8596870 | 0.88 | HTR2C (0.67) | HTR2CHTR2ADRD2DRD1DRD5 | |
| SCHEMBL8599014 | 0.82 | HTR2C (1.00) | HTR2CHTR2AMETAP1 | |
| SCHEMBL8595428 | 0.82 | HTR2C (1.00) | HTR2CHTR2AMETAP1 | |
| SCHEMBL8595714 | 0.82 | HTR2C (1.00) | HTR2CHTR2AMETAP1 | |
| SCHEMBL9238901 | 0.81 | HTR2A (0.55) | HTR2CHTR2ADRD2DRD1DRD5 | |
| SCHEMBL8596868 | 0.81 | HTR2C (0.65) | HTR2CHTR2ADRD2DRD1DRD5 | |
| Fumaric Acid SCHEMBL8875270 | 0.80 | HTR2A (0.47) | HTR2CHTR2AGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657426-A2 | Tricyclic pyrrole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-14 | — | — | EP | disclosed |