⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL923936 | 0.93 | TSHR (0.52) | — | |
| SCHEMBL3679041 | 0.91 | TSHR (0.56) | — | |
| SCHEMBL9484158 | 0.91 | TSHR (0.56) | — | |
| SCHEMBL9483889 | 0.91 | TSHR (0.56) | — | |
| SCHEMBL1005538 | 0.91 | TSHR (0.56) | — | |
| SCHEMBL9483035 | 0.91 | TSHR (0.56) | — | |
| SCHEMBL926526 | 0.85 | — | — | |
| SCHEMBL9423647 | 0.77 | TSHR (0.48) | — | |
| SCHEMBL8063790 | 0.76 | — | — | |
| SCHEMBL539394 | 0.74 | TSHR (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024110998-A1 | A STEROGENIC 3,3-DISUBSTITUTED 3-AMINO OXINDOLE COMPOUNDS AND A PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2024-05-30 | — | — | WO | claimed |
| US-20080161232-A1 | C5a is a cleavage product of the complement cascade, the CS convertase; antiinflammatory agents; autoimmune diseases; cyclic peptide compounds | JERINI AG (DE) | 2008-07-03 | — | — | US | claimed |
| EP-1838725-A1 | C5A RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2007-10-03 | — | — | EP | claimed |
| US-20070155712-A1 | Compounds for the inhibition of angiogenesis and use thereof | JERINI AG (DE) | 2007-07-05 | — | — | US | claimed |
| WO-2005090329-A9 | NEW COMPOUNDS FOR THE INHIBITION OF ANGIOGENESIS AND USE OF THEREOF | JERINI AG (DE) | 2007-02-01 | — | — | WO | claimed |
| EP-1727811-A1 | NEW COMPOUNDS FOR THE INHIBITION OF ANGIOGENESIS AND USE OF THEREOF | Jerini AG (DE) | 2006-12-06 | — | — | EP | claimed |
| US-20060183883-A1 | C5a Receptor antagonists | JERINI AG (DE) | 2006-08-17 | — | — | US | claimed |
| WO-2006074964-A1 | C5A RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2006-07-20 | — | — | WO | claimed |
| WO-2005090329-A1 | NEW COMPOUNDS FOR THE INHIBITION OF ANGIOGENESIS AND USE OF THEREOF | JERINI AG (DE) | 2005-09-29 | — | — | WO | claimed |
| EP-1438310-A1 | BETA-CARBOLIN DERIVATIVES AS PTP-INHIBITORS | TransTech Pharma Inc. (US) | 2004-07-21 | — | — | EP | claimed |
| WO-2003033496-A1 | BETA-CARBOLIN DERIVATIVES AS PTP-INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2003-04-24 | — | — | WO | claimed |
| WO-2024110998-A1 | A STEROGENIC 3,3-DISUBSTITUTED 3-AMINO OXINDOLE COMPOUNDS AND A PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2024-05-30 | — | — | WO | disclosed |
| US-20150005267-A1 | ANXIOLYTIC MARCGRAVIACEAE COMPOSITIONS CONTAINING BETULINIC ACID, BETULINIC ACID DERIVATIVES, AND METHODS | UNIV OTTAWA (CA) | 2015-01-01 | — | — | US | disclosed |
| EP-1727811-B1 | NEW COMPOUNDS FOR THE INHIBITION OF ANGIOGENESIS AND USE OF THEREOF | SHIRE ORPHAN THERAPIES GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| US-8623848-B2 | Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods | UNIVERSITY OF OTTAWA (CA) | 2014-01-07 | — | — | US | disclosed |
| EP-1438310-A1 | BETA-CARBOLIN DERIVATIVES AS PTP-INHIBITORS | TransTech Pharma Inc. (US) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003033496-A1 | BETA-CARBOLIN DERIVATIVES AS PTP-INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2003-04-24 | — | — | WO | disclosed |
| US-5191121-A | Sunscreen | KAO CORPORATION (JP) | 1993-03-02 | — | — | US | disclosed |
| US-5146002-A | Sunscreen | KAO CORPORATION (JP) | 1992-09-08 | — | — | US | disclosed |
| EP-0416564-A2 | Novel aroyl ketone derivative, UV ray absorber comprising the same, and cosmetic composition containing the same | KAO CORPORATION (JP) | 1991-03-13 | — | — | EP | disclosed |