Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.37 |
| ▸ | TOP1 | P11387 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9249913 | 0.92 | KCNH2 (0.41) | KCNH2PIM1GSK3AGSK3BPIM3 | |
| SCHEMBL9634933 | 0.79 | PIM1 (0.38) | KCNH2PIM1GSK3AGSK3BPIM3 | |
| SCHEMBL10730540 | 0.78 | KCNH2 (0.52) | KCNH2PIM1GSK3AGSK3BPIM3 | |
| SCHEMBL9129061 | 0.76 | PIM1 (0.37) | KCNH2PIM1GSK3AGSK3BPIM3 | |
| SCHEMBL9129070 | 0.76 | PIM1 (0.37) | KCNH2PIM1GSK3AGSK3BPIM3 | |
| SCHEMBL9215466 | 0.74 | KDM4E (0.33) | KCNH2PIM1GSK3AGSK3BPIM3 | |
| Pd-117558 SCHEMBL8922444 | 0.73 | KCNH2 (0.65) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| Pd-117558 SCHEMBL10529381 | 0.73 | KCNH2 (0.64) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL10574861 | 0.72 | KCNH2 (0.70) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL9457173 | 0.72 | KCNH2 (0.42) | KCNH2PIM1GSK3AGSK3BPIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476950-A | Aminopyrrolidine compound | DAIICHI SEIYAKU CO., LTD. (JP) | 1995-12-19 | — | — | US | disclosed |
| US-5416222-A | Chemical intermediates to prepare pyridinocarboxylic acid derivatives with high antimicrobial activity and excellent pharmacokinetics | DAIICHI SEIYAKU CO., LTD. (JP) | 1995-05-16 | — | — | US | disclosed |
| US-5380874-A | Pyrrolidine carbamates | DAIICHI SEIYAKU CO., LTD. (JP) | 1995-01-10 | — | — | US | disclosed |
| US-5098912-A | Bactericides for grampositive bacteria | DAIICHI SEIYAKU CO., LTD. (JP) | 1992-03-24 | — | — | US | disclosed |