Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 5/20 | 0.52 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pd-117558 SCHEMBL10529381 | 0.99 | KCNH2 (0.64) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL10676308 | 0.96 | KCNH2 (0.61) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL10678011 | 0.96 | KCNH2 (0.61) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL10680589 | 0.96 | KCNH2 (0.60) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL9666622 | 0.94 | KCNH2 (0.58) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL10574861 | 0.93 | KCNH2 (0.70) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| Hydrochloric Acid SCHEMBL10530523 | 0.92 | KCNH2 (0.62) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL10530717 | 0.92 | KCNH2 (0.64) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| SCHEMBL10530714 | 0.92 | ALDH1A1 (0.70) | KCNH2ALDH1A1POLBOPRM1CHRM2 | |
| Hydrochloric Acid SCHEMBL10573776 | 0.92 | KCNH2 (0.69) | KCNH2ALDH1A1POLBOPRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0236673-B1 | Process for quinoline-3-carboxylic acid antibacterial agents | WARNER LAMBERT CO (US) | 1994-07-13 | — | — | EP | claimed |
| EP-0235589-B1 | USE OF QUINOLONE AND NAPHTHYRIDINE ANTIBIOTICS FOR THE MANUFACTURE OF OPHTHALMIC MEDICAMENTS | WARNER-LAMBERT COMPANY (US) | 1992-10-28 | — | — | EP | claimed |
| EP-0198678-B1 | A PROCESS FOR PREPARING SUBSTITUTED QUINOLINE-3-CARBOXYLIC ACIDS | WARNER-LAMBERT COMPANY (US) | 1991-08-21 | — | — | EP | claimed |
| EP-0200307-B1 | IMPROVED PROCESS FOR PRODUCTION OF QUINOLINE-3-CARBOXYLIC ACID ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-12-20 | — | — | EP | claimed |
| US-4772706-A | Process for quinoline-3-carboxylic acid antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1988-09-20 | — | — | US | claimed |
| EP-0236673-A2 | Process for quinoline-3-carboxylic acid antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1987-09-16 | — | — | EP | claimed |
| EP-0235589-A2 | Use of quinolone and naphthyridine antibiotics for the manufacture of ophthalmic medicaments | WARNER-LAMBERT COMPANY (US) | 1987-09-09 | — | — | EP | claimed |
| US-4692454-A | Opthalmic use of quinolone antibiotics | WARNER-LAMBERT COMPANY (US) | 1987-09-08 | — | — | US | claimed |
| US-4665079-A | QUINOLINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1987-05-12 | — | — | US | claimed |
| EP-0200307-A1 | Improved process for production of quinoline-3-carboxylic acid antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-11-05 | — | — | EP | claimed |
| EP-0198678-A2 | A process for preparing substituted quinoline-3-carboxylic acids | WARNER-LAMBERT COMPANY (US) | 1986-10-22 | — | — | EP | claimed |
| US-4578473-A | Process for quinoline-3-carboxylic acid antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-03-25 | — | — | US | claimed |
| EP-0153163-A2 | 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | claimed |
| EP-2293778-B1 | COMPOSITION COMPRISING AN ANTIBIOTIC AND MOMETASONE | INTERVET INT BV (NL) | 2013-09-18 | — | — | EP | disclosed |
| US-20120046259-A1 | COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID | INTERVET INC. | 2012-02-23 | — | — | US | disclosed |
| US-20120046259-A1 | COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID | INTERVET INC. | 2012-02-23 | — | — | US | disclosed |
| EP-0200307-A1 | Improved process for production of quinoline-3-carboxylic acid antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-11-05 | — | — | EP | disclosed |
| EP-0198678-A2 | A process for preparing substituted quinoline-3-carboxylic acids | WARNER-LAMBERT COMPANY (US) | 1986-10-22 | — | — | EP | disclosed |
| US-4578473-A | Process for quinoline-3-carboxylic acid antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1986-03-25 | — | — | US | disclosed |
| EP-0153163-A2 | 7-Substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046259-A1 | COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID | CYP21A2, CYP27A1, NR3C2 | KCNH2 2951/4885ALDH1A1 1287/4885POLB 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.