SCHEMBL9244657

SCHEMBL9244657

O=C(/C=C/C(=O)OC(F)(F)CF)Oc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.50
ZDHHC2 Q9UIJ5 1/20 0.43
HPGD P15428 2/20 0.40
HSD17B10 Q99714 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MAPT P10636 1/20 0.40
KMT2A Q03164 3/20 0.40
MEN1 O00255 1/20 0.39
HTR1A P08908 1/20 0.38
THRB P10828 1/20 0.37
HCAR2 Q8TDS4 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
ATM Q13315 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
ALOX15 P16050 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15822003 0.81 HDAC1 (0.41) MAOBHPGDHSD17B10MAPTHDAC1
SCHEMBL1255834 0.80 KEAP1 (0.32) HCAR2
SCHEMBL1249384 0.78 HPGD (0.57) MAOBZDHHC2HPGDHSD17B10KDM4E
SCHEMBL356193 0.78 HPGD (0.57) MAOBZDHHC2HPGDHSD17B10KDM4E
SCHEMBL356194 0.78 HPGD (0.57) MAOBZDHHC2HPGDHSD17B10KDM4E
SCHEMBL29117083 0.78 MAOB (0.57) MAOBZDHHC2HPGDHSD17B10KDM4E
SCHEMBL29083508 0.76 HPGD (0.55) MAOBZDHHC2HPGDHSD17B10KDM4E
SCHEMBL9244671 0.75 MAOB (0.55) MAOBZDHHC2HPGDHSD17B10KDM4E
SCHEMBL9244660 0.75 MAOB (0.55) MAOBZDHHC2HPGDHSD17B10KDM4E
SCHEMBL9241880 0.75 MAOB (0.48) MAOBZDHHC2HPGDHSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0434362-B1 Graft copolymer, solution containing the graft copolymer, and method of treating contact lens with the solution TOMEI SANGYO KK (JP) 1995-03-22 EP disclosed
EP-0433046-B1 Polymer-type polymerization initiator TOMEI SANGYO KK (JP) 1994-08-10 EP disclosed
US-5206298-A GRAFT COPOLYMER, SOLUTION CONTAINING THE GRAFT COPOLYMER FOR TREATING CONTACT LENS, AND METHOD OF TREATING CONTACT LENS WITH THE SOLUTION AND MAKING HYDROPHILIC LENS SURFACE TOMEI SANGYO KABUSHIKI KAISHA (JP) 1993-04-27 US disclosed
US-5082912-A For graft polymerization, surfactants TOMEI SANGYO KABUSHIKI KAISHA (JP) 1992-01-21 US disclosed
EP-0434362-A1 Graft copolymer, solution containing the graft copolymer, and method of treating contact lens with the solution Tomei Sangyo Kabushiki Kaisha (JP) 1991-06-26 EP disclosed
EP-0433046-A2 Polymer-type polymerization initiator Tomei Sangyo Kabushiki Kaisha (JP) 1991-06-19 EP disclosed