Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 8/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.48 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.48 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924841 | 0.89 | PI4KB (0.49) | PI4KBCYP3A4PIK3C2APIK3C2BSTK17A | |
| SCHEMBL924341 | 0.87 | PI4KB (0.48) | PI4KBCYP3A4PIK3C2APIK3C2BSTK17A | |
| Trifluoroacetic Acid SCHEMBL924501 | 0.80 | PIK3CG (0.55) | PI4KBCYP3A4PIK3C2APIK3C2BSTK17A | |
| SCHEMBL924743 | 0.80 | PIK3CB (0.68) | PI4KBPIK3C2APIK3C2BPIK3CDPIK3CG | |
| SCHEMBL925027 | 0.78 | PIK3CG (0.64) | PI4KBPIK3C2APIK3C2BPIK3CDPIK3CG | |
| SCHEMBL926038 | 0.78 | PIK3CD (0.75) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3C3 | |
| SCHEMBL924529 | 0.77 | PIK3CG (0.45) | PI4KBPIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL925661 | 0.77 | PIK3CD (0.65) | PI4KBPIK3C2APIK3C2BPIK3CDPIK3CG | |
| SCHEMBL925874 | 0.77 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CBPIK3CAPIK3C3 | |
| SCHEMBL924504 | 0.77 | PIK3CB (0.54) | PI4KBPIK3C2APIK3C2BPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868188-B2 | 5-heteroaryl thiazoles and their use as PI3K inhibitors | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | disclosed |
| EP-1841763-B1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | ASTRAZENECA AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | ASTRAZENECA AB (SE) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | MTOR, PIK3R5, PIK3CA | PI4KB 29/4885CYP3A4 703/4885PIK3C2A 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.