Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL924528 | 0.82 | PIK3CG (0.54) | PIK3CGPIK3CAPIK3CDPIK3CBMAPT | |
| SCHEMBL924341 | 0.80 | PI4KB (0.48) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL924922 | 0.80 | PIK3CG (0.61) | PIK3CGPIK3CAPIK3CDPIK3CBMAPT | |
| SCHEMBL924841 | 0.78 | PI4KB (0.49) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL924503 | 0.77 | PI4KB (0.48) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL924743 | 0.75 | PIK3CB (0.68) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL926035 | 0.75 | PIK3CD (0.62) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL925319 | 0.75 | PIK3CD (0.60) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB | |
| SCHEMBL12992139 | 0.74 | PIK3CG (0.52) | PIK3CGPIK3CAPI4KB | |
| SCHEMBL12991794 | 0.74 | PIK3CG (0.51) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868188-B2 | 5-heteroaryl thiazoles and their use as PI3K inhibitors | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | disclosed |
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | ASTRAZENECA AB (SE) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | MTOR, PIK3R5, PIK3CA | PIK3CG 16/4885PIK3CA 3/4885PIK3CD 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.