Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.41 |
| ▸ | TET3 | O43151 | 2/20 | 0.41 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL9406592 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2TET2TET3TET1SLC22A6 | |
| SCHEMBL30293 | 0.88 | TDP1 (0.48) | SMN1; SMN2SLC22A6TDP1GABRR1LMNA | |
| Ammonia Solution, Strong SCHEMBL28156292 | 0.85 | TDP1 (0.52) | SMN1; SMN2SLC22A6TDP1GABRR1LMNA | |
| SCHEMBL8558212 | 0.85 | TDP1 (0.46) | SMN1; SMN2SLC22A6TDP1GABRR1LMNA | |
| SCHEMBL9053647 | 0.85 | TDP1 (0.46) | SMN1; SMN2SLC22A6TDP1GABRR1LMNA | |
| SCHEMBL9406869 | 0.85 | TDP1 (0.46) | SMN1; SMN2SLC22A6TDP1GABRR1LMNA | |
| SCHEMBL9406499 | 0.85 | TDP1 (0.46) | SMN1; SMN2SLC22A6TDP1GABRR1LMNA | |
| Malic Acid SCHEMBL98496 | 0.83 | — | — | |
| Malic Acid SCHEMBL856 | 0.83 | — | — | |
| Malic Acid SCHEMBL89131 | 0.83 | SMN1; SMN2 (1.00) | SMN1; SMN2TET2TET3TET1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320213-B1 | Improved, controlled temperature process for making 2,2'-oxodisuccinates useful as laundry detergent builders | PROCTER & GAMBLE (US) | 1995-03-08 | — | — | EP | disclosed |
| CN-1037171-A | Improved temperature control process for the preparation of 2, 2-oxodisuccinates as laundry detergent builders | PROCTER & GAMBLE (US) | 1989-11-15 | — | — | CN | disclosed |
| EP-0320213-A2 | Improved, controlled temperature process for making 2,2'-oxodisuccinates useful as laundry detergent builders | THE PROCTER & GAMBLE COMPANY (US) | 1989-06-14 | — | — | EP | disclosed |