Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL924994 | 0.94 | PIK3CA (0.59) | RIPK1PIK3CBPIK3CAPIK3CDPIK3CG | |
| Trifluoroacetic Acid SCHEMBL924461 | 0.92 | PIK3CA (0.54) | RIPK1PIK3CBPIK3CAPIK3CDPIK3CG | |
| Trifluoroacetic Acid SCHEMBL924714 | 0.92 | RIPK1 (0.65) | RIPK1PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL924535 | 0.86 | RIPK1 (0.71) | RIPK1PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL924624 | 0.86 | PIK3CA (0.58) | RIPK1PIK3CBPIK3CAPIK3CDPIK3CG | |
| Trifluoroacetic Acid SCHEMBL924653 | 0.85 | PIK3CB (0.62) | RIPK1PIK3CBPIK3CAPIK3CDPIK3CG | |
| Trifluoroacetic Acid SCHEMBL925318 | 0.82 | PIK3CB (0.71) | PIK3CBPIK3CAPIK3CDPIK3CGPI4KB | |
| SCHEMBL927290 | 0.80 | PIK3CD (0.75) | PIK3CBPIK3CAPIK3CDPIK3CGPI4KB | |
| SCHEMBL924631 | 0.80 | PIK3CA (0.55) | PIK3CBPIK3CAPIK3CDPIK3CGPI4KB | |
| Trifluoroacetic Acid SCHEMBL925885 | 0.80 | PIK3CB (0.56) | RIPK1PIK3CBPIK3CAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868188-B2 | 5-heteroaryl thiazoles and their use as PI3K inhibitors | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | disclosed |
| EP-1841763-B1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | ASTRAZENECA AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | ASTRAZENECA AB (SE) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | MTOR, PIK3R5, PIK3CA | RIPK1 801/4885PIK3CB 18/4885PIK3CA 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.