SCHEMBL9247403

SCHEMBL9247403

CCC[C@H]1CC[C@H](CCc2ccc(F)c(F)c2F)CC1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 1/20 0.36
HTR2A P28223 5/20 0.35
HTR2C P28335 5/20 0.35
P2RX7 Q99572 5/20 0.35
CYP2C9 P11712 1/20 0.35
MAOB P27338 2/20 0.35
MAOA P21397 1/20 0.35
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
MEN1 O00255 1/20 0.33
MAPK1 P28482 1/20 0.33
KMT2A Q03164 1/20 0.33
CEL P19835 1/20 0.33
CYP2D6 P10635 1/20 0.32
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
KCNH2 Q12809 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9247410 1.00 RIPK1 (0.36) RIPK1HTR2AHTR2CP2RX7CYP2C9
SCHEMBL9247386 0.95 HTR2A (0.36) RIPK1HTR2AHTR2CP2RX7CYP2C9
SCHEMBL9247392 0.95 HTR2A (0.36) RIPK1HTR2AHTR2CP2RX7CYP2C9
SCHEMBL10709502 0.93 CYP2C9 (0.38) HTR2AHTR2CCYP2C9MAOBMAOA
SCHEMBL10709504 0.93 CYP2C9 (0.38) HTR2AHTR2CCYP2C9MAOBMAOA
SCHEMBL9249614 0.90 CYP1A2 (0.39) RIPK1HTR2AHTR2CP2RX7CYP2C9
SCHEMBL9249619 0.90 CYP1A2 (0.39) RIPK1HTR2AHTR2CP2RX7CYP2C9
SCHEMBL9251450 0.90 RIPK1 (0.36) RIPK1HTR2AHTR2CP2RX7MAOB
SCHEMBL9251454 0.90 RIPK1 (0.36) RIPK1HTR2AHTR2CP2RX7MAOB
SCHEMBL13136427 0.90 CYP2C9 (0.36) HTR2AHTR2CCYP2C9MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995010496-A1 2,3,4-TRIFLUOROBENZENES AND THEIR USE IN LIQUID CRYSTAL MIXTURES MERCK PATENT GMBH (DE) 1995-04-20 WO disclosed