Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9247442 | 1.00 | GRM2 (0.37) | GRM2PTGESGRM5BACE1BACE2 | |
| SCHEMBL9247454 | 1.00 | GRM2 (0.37) | GRM2PTGESGRM5BACE1BACE2 | |
| SCHEMBL9247447 | 1.00 | GRM2 (0.37) | GRM2PTGESGRM5BACE1BACE2 | |
| SCHEMBL9244993 | 0.91 | PTGES (0.36) | GRM2PTGESGRM5BACE1BACE2 | |
| SCHEMBL9244982 | 0.91 | PTGES (0.36) | GRM2PTGESGRM5BACE1BACE2 | |
| SCHEMBL9244989 | 0.91 | PTGES (0.36) | GRM2PTGESGRM5BACE1BACE2 | |
| SCHEMBL9244978 | 0.91 | PTGES (0.36) | GRM2PTGESGRM5BACE1BACE2 | |
| SCHEMBL9246651 | 0.89 | GRM2 (0.38) | GRM2PTGESGRM5BACE1BACE2 | |
| SCHEMBL9246662 | 0.89 | GRM2 (0.38) | GRM2PTGESGRM5BACE1BACE2 | |
| SCHEMBL9246666 | 0.89 | GRM2 (0.38) | GRM2PTGESGRM5BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5447657-A | Liquid crystal compounds | HOFFMANN-LA ROCHE INC. (US) | 1995-09-05 | — | — | US | disclosed |