⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10363927 | 0.94 | PAOX (0.46) | — | |
| SCHEMBL10364309 | 0.92 | EPHX1 (0.48) | — | |
| SCHEMBL10363416 | 0.92 | EPHX1 (0.48) | — | |
| SCHEMBL10365395 | 0.89 | PAOX (0.41) | — | |
| SCHEMBL10364451 | 0.86 | PAOX (0.45) | — | |
| SCHEMBL26367204 | 0.85 | CYP2C19 (0.53) | — | |
| SCHEMBL9487092 | 0.85 | CA12 (0.47) | — | |
| SCHEMBL3024820 | 0.85 | CYP2C19 (0.53) | — | |
| SCHEMBL10363933 | 0.84 | EPHX1 (0.46) | — | |
| SCHEMBL10364507 | 0.83 | PAOX (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0473673-A4 | METHOD FOR PROTECTION FROM AZT SIDE EFFECTS AND TOXICITY | US BIOSCIENCE (US) | 1995-05-17 | — | — | EP | disclosed |
| EP-0473673-A1 | METHOD FOR PROTECTION FROM AZT SIDE EFFECTS AND TOXICITY | U.S. BIOSCIENCE (US) | 1992-03-11 | — | — | EP | disclosed |
| EP-0391971-A4 | IMPROVING TOXICITY PROFILES IN CHEMOTHERAPY | — | 1991-10-02 | — | — | EP | disclosed |
| WO-1990014007-A1 | METHOD FOR PROTECTION FROM AZT SIDE EFFECTS AND TOXICITY | U.S. BIOSCIENCE (US) | 1990-11-29 | — | — | WO | disclosed |
| EP-0391971-A1 | IMPROVING TOXICITY PROFILES IN CHEMOTHERAPY. | US BIOSCIENCE (US) | 1990-10-17 | — | — | EP | disclosed |
| US-4918107-A | HYDROXYPHENYLACETYL-L-ASPARAGINYL COMPOUNDS | TSUMURA & CO. (JP) | 1990-04-17 | — | — | US | disclosed |
| WO-1989005637-A1 | IMPROVING TOXICITY PROFILES IN CHEMOTHERAPY | U.S. BIOSCIENCE (US) | 1989-06-29 | — | — | WO | disclosed |