Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.58 |
| ▸ | GAA | P10253 | 7/20 | 0.58 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.56 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.53 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.53 |
| ▸ | TYR | P14679 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762492 | 0.80 | SPHK2 (0.46) | RAB9AKMT2AGAATRPV4SMN1; SMN2 | |
| SCHEMBL12215995 | 0.79 | RAB9A (0.65) | RAB9AKMT2AGAATRPV4SMN1; SMN2 | |
| SCHEMBL9072510 | 0.78 | RAB9A (0.68) | RAB9AKMT2AGAASMN1; SMN2MAPT | |
| SCHEMBL191576 | 0.75 | GCK (0.59) | RAB9AKMT2AGAASMN1; SMN2MAPT | |
| SCHEMBL1328439 | 0.75 | GCK (0.60) | RAB9AKMT2AGAASMN1; SMN2MAPT | |
| SCHEMBL1328161 | 0.75 | GCK (0.60) | RAB9AKMT2AGAASMN1; SMN2MAPT | |
| SCHEMBL4548018 | 0.73 | GAA (1.00) | RAB9AKMT2AGAATRPV4SMN1; SMN2 | |
| SCHEMBL15993435 | 0.73 | KMT2A (0.67) | RAB9AKMT2AGAATRPV4SMN1; SMN2 | |
| SCHEMBL3377675 | 0.73 | GCK (0.63) | RAB9AKMT2AGAASMN1; SMN2MAPT | |
| SCHEMBL18281285 | 0.72 | MEN1 (1.00) | RAB9AKMT2AGAATRPV4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868188-B2 | 5-heteroaryl thiazoles and their use as PI3K inhibitors | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | disclosed |
| EP-1841763-B1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | ASTRAZENECA AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | ASTRAZENECA AB (SE) | 2008-06-05 | — | — | US | disclosed |
| EP-1841763-A1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | AstraZeneca AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006051270-A1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS P13K INHIBITORS | ASTRAZENECA AB (SE) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | MTOR, PIK3R5, PIK3CA | RAB9A 675/4885KMT2A 2805/4885GAA 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.