SCHEMBL9250852

SCHEMBL9250852

CC[C@H]1CC[C@H](COc2cc(F)c(F)c(F)c2F)CC1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 10/20 0.36
HTR2A P28223 2/20 0.36
HTR2C P28335 2/20 0.36
HTR2B P41595 2/20 0.36
RIPK1 Q13546 1/20 0.36
ACACB O00763 1/20 0.35
PDE4A P27815 1/20 0.35
PDE4B Q07343 1/20 0.35
PDE4C Q08493 1/20 0.35
PDE4D Q08499 1/20 0.35
SCN5A Q14524 1/20 0.34
CNR2 P34972 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9250854 1.00 SCN9A (0.36) SCN9AHTR2AHTR2CHTR2BRIPK1
SCHEMBL9250443 0.95 SCN9A (0.35) SCN9AHTR2AHTR2CHTR2BRIPK1
SCHEMBL9250446 0.95 SCN9A (0.35) SCN9AHTR2AHTR2CHTR2BRIPK1
SCHEMBL9248852 0.88 RIPK1 (0.37) SCN9AHTR2AHTR2CHTR2BRIPK1
SCHEMBL9248853 0.88 RIPK1 (0.37) SCN9AHTR2AHTR2CHTR2BRIPK1
SCHEMBL9247363 0.85 CYP1A2 (0.36) SCN9AHTR2AHTR2CHTR2BRIPK1
SCHEMBL9247370 0.85 CYP1A2 (0.36) SCN9AHTR2AHTR2CHTR2BRIPK1
SCHEMBL9250697 0.84 RIPK1 (0.35) SCN9AHTR2AHTR2CHTR2BRIPK1
SCHEMBL9250703 0.84 RIPK1 (0.35) SCN9AHTR2AHTR2CHTR2BRIPK1
SCHEMBL9251116 0.81 SCN9A (0.33) SCN9AHTR2AHTR2CHTR2BRIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995010495-A1 2,3,4,5-TETRAFLUOROBENZENES AND THEIR USE IN LIQUID CRYSTAL MIXTURES MERCK PATENT GMBH (DE) 1995-04-20 WO disclosed