Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 6/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | JAK1 | P23458 | 4/20 | 0.42 |
| ▸ | TYK2 | P29597 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9251533 | 0.91 | PTGER4 (0.51) | PTGER4ITGB3ITGA2BJAK2JAK1 | |
| SCHEMBL9248766 | 0.90 | ITGB3 (0.45) | PTGER4ITGB3ITGA2BJAK2JAK1 | |
| SCHEMBL9248459 | 0.90 | ITGB3 (0.45) | PTGER4ITGB3ITGA2BJAK2JAK1 | |
| SCHEMBL9248450 | 0.90 | ITGB3 (0.45) | PTGER4ITGB3ITGA2BJAK2JAK1 | |
| SCHEMBL9254834 | 0.89 | ITGB3 (0.44) | PTGER4ITGB3ITGA2BJAK2JAK1 | |
| SCHEMBL9255435 | 0.89 | PTGER4 (0.52) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9255433 | 0.88 | JAK2 (0.50) | PTGER4ITGB3ITGA2BJAK2JAK1 | |
| SCHEMBL9252622 | 0.86 | JAK2 (0.48) | PTGER4ITGB3ITGA2BJAK2JAK1 | |
| SCHEMBL9248802 | 0.86 | PTGER4 (0.52) | PTGER4ITGB3ITGA2BJAK2JAK1 | |
| SCHEMBL9248925 | 0.85 | PTGER4 (0.51) | PTGER4JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |