Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 9/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | TYK2 | P29597 | 5/20 | 0.41 |
| ▸ | JAK3 | P52333 | 5/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9248459 | 0.92 | ITGB3 (0.45) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9251533 | 0.90 | PTGER4 (0.51) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9257280 | 0.90 | PTGER4 (0.44) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9255102 | 0.89 | PTGER4 (0.47) | PTGER4JAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL9248958 | 0.89 | PTGER4 (0.46) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9256221 | 0.89 | PTGER4 (0.43) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9252530 | 0.88 | PTGER4 (0.51) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9255359 | 0.86 | PTGER4 (0.49) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9248450 | 0.85 | ITGB3 (0.45) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9251820 | 0.85 | PTGER4 (0.58) | PTGER4JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |