Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.53 |
| ▸ | JAK1 | P23458 | 9/20 | 0.53 |
| ▸ | TYK2 | P29597 | 9/20 | 0.53 |
| ▸ | JAK3 | P52333 | 9/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9254679 | 0.91 | SIRT2 (0.51) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9248154 | 0.90 | JAK2 (0.55) | JAK2JAK1TYK2JAK3PTGER4 | |
| Acetic Acid SCHEMBL9248143 | 0.89 | JAK2 (0.56) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9253691 | 0.89 | JAK2 (0.60) | JAK2JAK1TYK2JAK3PTGER4 | |
| Hydrochloric Acid SCHEMBL9254291 | 0.88 | JAK2 (0.59) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9253585 | 0.88 | PTGER4 (0.47) | JAK2JAK1TYK2JAK3PTGER4 | |
| Hydrochloric Acid SCHEMBL9252320 | 0.87 | HDAC1 (0.51) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9253878 | 0.87 | JAK2 (0.51) | JAK2JAK1TYK2JAK3PTGER4 | |
| Hydrochloric Acid SCHEMBL9251326 | 0.86 | ENPP2 (0.58) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9248594 | 0.84 | HDAC1 (0.50) | PTGER4RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |