Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9933687 | 0.83 | HDAC4 (0.41) | GRM5ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL7666711 | 0.75 | MAPK1 (0.56) | ALDH1A1MEN1PKMKMT2AMAPK1 | |
| SCHEMBL1619449 | 0.74 | ALDH1A1 (0.68) | ALDH1A1MEN1PKMKMT2ATSHR | |
| SCHEMBL25238058 | 0.72 | MAPK1 (0.56) | ALDH1A1MEN1PKMKMT2AMAPK1 | |
| SCHEMBL31202611 | 0.72 | MAPK1 (0.56) | ALDH1A1MEN1PKMKMT2AMAPK1 | |
| SCHEMBL5653134 | 0.71 | MAPK1 (0.55) | ALDH1A1MEN1PKMKMT2AMAPK1 | |
| SCHEMBL4651618 | 0.71 | MAPK1 (0.59) | ALDH1A1MEN1PKMKMT2AMAPK1 | |
| SCHEMBL8217760 | 0.70 | POLB (0.48) | GRM5ALDH1A1MEN1PKMKMT2A | |
| SCHEMBL8052946 | 0.70 | MEN1 (0.40) | GRM5ALDH1A1MEN1PKMKMT2A | |
| SCHEMBL7503789 | 0.70 | MAPK1 (0.43) | ALDH1A1MEN1PKMKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5395838-A | Aromatic aminomethyl substitutes compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-03-07 | — | — | US | disclosed |
| EP-0373891-B1 | Anti-tumour agents | ICI PLC (GB) | 1994-11-02 | — | — | EP | disclosed |
| US-5252573-A | Quinazoline derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-10-12 | — | — | US | disclosed |
| US-5089499-A | Anticarcinogenic agents; thymidylate synthetase inhibitors; antiallergens; psoriasis | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-18 | — | — | US | disclosed |
| EP-0373891-A2 | Anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-06-20 | — | — | EP | disclosed |