Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 6/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9251326 | 0.89 | ENPP2 (0.58) | ENPP2JAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL9095373 | 0.88 | ENPP2 (0.58) | ENPP2JAK2JAK1TYK2JAK3 | |
| SCHEMBL9256202 | 0.86 | JAK2 (0.55) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9248891 | 0.85 | JAK2 (0.52) | ENPP2JAK2JAK1TYK2JAK3 | |
| SCHEMBL9253691 | 0.84 | JAK2 (0.60) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9247747 | 0.84 | PTGER4 (0.49) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL9248557 | 0.83 | ENPP2 (0.59) | ENPP2JAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL9254291 | 0.83 | JAK2 (0.59) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9255820 | 0.83 | ADORA2A (0.54) | JAK2JAK1TYK2JAK3PTGER4 | |
| Bromide SCHEMBL9252006 | 0.83 | ENPP2 (0.58) | ENPP2JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |