Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 12/20 | 0.48 |
| ▸ | BACE1 | P56817 | 3/20 | 0.46 |
| ▸ | CCR3 | P51677 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253200 | 1.00 | ACHE (0.48) | ACHEBACE1CCR3ALDH1A1DRD2 | |
| SCHEMBL9252315 | 0.92 | ACHE (0.48) | ACHEBACE1CCR3DRD2HTR2A | |
| SCHEMBL4508009 | 0.89 | ACHE (0.52) | ACHEBACE1ALDH1A1 | |
| SCHEMBL4508006 | 0.89 | ACHE (0.52) | ACHEBACE1ALDH1A1 | |
| SCHEMBL9260222 | 0.88 | ACHE (0.48) | ACHEBACE1 | |
| SCHEMBL9260220 | 0.88 | ACHE (0.48) | ACHEBACE1 | |
| SCHEMBL9259751 | 0.85 | ACHE (0.63) | ACHEBACE1ALDH1A1DRD2HTR2A | |
| SCHEMBL9259753 | 0.85 | ACHE (0.63) | ACHEBACE1ALDH1A1DRD2HTR2A | |
| SCHEMBL9844714 | 0.85 | ACHE (0.50) | ACHEBACE1 | |
| SCHEMBL9844717 | 0.85 | ACHE (0.50) | ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | claimed |
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |