Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28004766 | 0.83 | EPHX2 (0.44) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL6153995 | 0.82 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL6153998 | 0.82 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL11649576 | 0.81 | KMT2A (0.54) | SMN1; SMN2GAAHSD17B10KMT2APRSS1 | |
| SCHEMBL28820759 | 0.80 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL7561649 | 0.77 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL2588306 | 0.77 | GAA (0.68) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL31530566 | 0.76 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL255251 | 0.76 | GAA (0.76) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL13862225 | 0.76 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2GAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5382665-A | Synthesis of oxazolines and oxazines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 1995-01-17 | — | — | US | disclosed |