SCHEMBL92538

SCHEMBL92538

O=C[C@H]1CC[C@H](OC[C@@H]2C[C@H](N3CCN(CC(F)(F)F)CC3)CN2C(=O)Cc2cc(Cl)c(NC(=O)c3coc4ccccc34)cc2F)CC1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 20/20 0.51
ITGB1 P05556 17/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13698637 1.00 ITGA4 (0.51) ITGA4ITGB1
SCHEMBL92548 0.95 ITGA4 (0.49) ITGA4ITGB1
SCHEMBL10273041 0.93 ITGB1 (0.44) ITGA4ITGB1
SCHEMBL84769 0.93 ITGB1 (0.60) ITGA4ITGB1
SCHEMBL93091 0.91 ITGB1 (0.51) ITGA4ITGB1
SCHEMBL92640 0.90 ITGA4 (0.52) ITGA4ITGB1
SCHEMBL92648 0.90 ITGA4 (0.55) ITGA4ITGB1
SCHEMBL10273151 0.89 ITGA4 (0.54) ITGA4ITGB1
SCHEMBL92486 0.89 ITGA4 (0.55) ITGA4ITGB1
SCHEMBL92561 0.88 ITGA4 (0.51) ITGA4ITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129366-B2 VLA-4 inhibitory drug DAIICHI SANKYO COMPANY, LIMITED (JP) 2012-03-06 US disclosed