SCHEMBL9254564

SCHEMBL9254564

COc1cccc2c1CCCC2C=CCCl

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
SIGMAR1 Q99720 6/20 0.48
TAS1R3 Q7RTX0 1/20 0.46
TAS1R1 Q7RTX1 1/20 0.46
TAS1R2 Q8TE23 1/20 0.46
CYP19A1 P11511 1/20 0.45
CHRM2 P08172 1/20 0.43
CHRM4 P08173 1/20 0.43
ABCB1 P08183 1/20 0.43
CHRM5 P08912 1/20 0.43
ADRA2A P08913 1/20 0.43
CHRM1 P11229 1/20 0.43
ADRA2B P18089 1/20 0.43
ADRA2C P18825 1/20 0.43
CHRM3 P20309 1/20 0.43
KCNH2 Q12809 1/20 0.43
TMEM97 Q5BJF2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28069851 0.80 CA1 (0.56) CA1CA2SIGMAR1TAS1R3TAS1R1
SCHEMBL9250189 0.77 SIGMAR1 (0.63) SIGMAR1
SCHEMBL29028639 0.76 CA1 (0.48) CA1CA2SIGMAR1TAS1R3TAS1R1
SCHEMBL7680743 0.74 CA1 (0.55) CA1CA2SIGMAR1TAS1R3TAS1R1
SCHEMBL9248916 0.73 SIGMAR1 (0.65) SIGMAR1
SCHEMBL9005283 0.72 CA1 (0.56) CA1CA2SIGMAR1CHRM2CHRM4
SCHEMBL7510096 0.71 CA1 (0.55) CA1CA2SIGMAR1TAS1R3TAS1R1
SCHEMBL10602964 0.71 CA1 (0.58) CA1CA2SIGMAR1TAS1R3TAS1R1
SCHEMBL15161143 0.71 CA1 (0.55) CA1CA2SIGMAR1TAS1R3TAS1R1
SCHEMBL1565397 0.71 CA1 (0.58) CA1CA2SIGMAR1TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0647222-A1 N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY PHARMACIA & UPJOHN S.p.A. (IT) 1995-04-12 EP disclosed
WO-1994000441-A1 N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY FARMITALIA CARLO ERBA S.R.L. (IT) 1994-01-06 WO disclosed