Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 10/20 | 0.68 |
| ▸ | AKR1A1 | P14550 | 3/20 | 0.68 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9257211 | 0.89 | AKR1B1 (0.66) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL9184546 | 0.88 | AKR1B1 (0.65) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL9181175 | 0.88 | AKR1B1 (0.65) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL9254962 | 0.88 | AKR1B1 (0.68) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL10574757 | 0.88 | AKR1B1 (0.65) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL10571505 | 0.86 | AKR1B1 (0.62) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL9836968 | 0.86 | AKR1B1 (0.62) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL10576515 | 0.83 | AKR1B1 (0.59) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL10607407 | 0.83 | AKR1B1 (0.74) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL10575326 | 0.81 | AKR1B1 (0.69) | AKR1B1AKR1A1AKR1B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0193415-B1 | SPIRO-3-HETEROAZOLIDINE COMPOUNDS AND SALTS THEREOF, THEIR PREPARATION AND PHARMACEUTICAL AGENTS THEREOF | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-06-26 | — | — | EP | claimed |
| EP-0264586-B1 | HYDANTOIN DERIVATIVES FOR TREATING COMPLICATIONS OF DIABETES | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-04-03 | — | — | EP | claimed |
| EP-0264586-A1 | Hydantoin derivatives for treating complications of diabetes | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1988-04-27 | — | — | EP | claimed |
| US-4740517-A | INHIBIT ALDOSE REDUCTASE | SANWA KAGAKU KENYUSHO CO., LTD. (JP) | 1988-04-26 | — | — | US | claimed |
| US-5447946-A | Inhibitors of aldose reductase | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-09-05 | — | — | US | disclosed |
| EP-0193415-B1 | SPIRO-3-HETEROAZOLIDINE COMPOUNDS AND SALTS THEREOF, THEIR PREPARATION AND PHARMACEUTICAL AGENTS THEREOF | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-06-26 | — | — | EP | disclosed |
| EP-0264586-B1 | HYDANTOIN DERIVATIVES FOR TREATING COMPLICATIONS OF DIABETES | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-5001240-A | Process for preparing optically active hydantoins | SANWA KAGAKU KENKYYUSHO CO., LTD. (JP) | 1991-03-19 | — | — | US | disclosed |
| US-4985574-A | CHEMICAL INTERMEDIATES, BENZOPYRAN COMPOUNDS | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| US-4985573-A | Chemical Intermediates | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| US-4978758-A | REACTING OPTICALLY ACTIVE 3,4-DIHYDRO-4-OXO-2H-1-BENZOPYRAN-2-CARBOXYLIC ACID DERIVATIVES WITH ALKALI METAL CYANIDE AND AMMONIUM CARBONATE, ESTERIFYING, AMIDATING | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1990-12-18 | — | — | US | disclosed |
| US-4861792-A | Hydantoin derivatives for treating complications of diabetes | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1989-08-29 | — | — | US | disclosed |
| EP-0264586-A1 | Hydantoin derivatives for treating complications of diabetes | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1988-04-27 | — | — | EP | disclosed |
| US-4740517-A | INHIBIT ALDOSE REDUCTASE | SANWA KAGAKU KENYUSHO CO., LTD. (JP) | 1988-04-26 | — | — | US | disclosed |
| EP-0193415-A2 | Spiro-3-heteroazolidine compounds and salts thereof, their preparation and pharmaceutical agents thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1986-09-03 | — | — | EP | disclosed |