Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 7/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9256921 | 0.99 | PTGER4 (0.56) | PTGER4SIRT2SIRT1SIRT3LMNA | |
| SCHEMBL8863445 | 0.92 | PTGER4 (0.48) | PTGER4SIRT2SIRT1SIRT3JAK2 | |
| SCHEMBL9248925 | 0.91 | PTGER4 (0.51) | PTGER4SIRT2SIRT1SIRT3JAK2 | |
| SCHEMBL9248802 | 0.90 | PTGER4 (0.52) | PTGER4SIRT2SIRT1SIRT3JAK2 | |
| SCHEMBL9252530 | 0.90 | PTGER4 (0.51) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9255857 | 0.89 | PTGER4 (0.49) | PTGER4SIRT2SIRT1SIRT3JAK2 | |
| SCHEMBL9251758 | 0.89 | PTGER4 (0.56) | PTGER4KMT2AMEN1 | |
| SCHEMBL9253890 | 0.88 | PTGER4 (0.49) | PTGER4SIRT2SIRT1JAK2JAK1 | |
| SCHEMBL9251820 | 0.88 | PTGER4 (0.58) | PTGER4JAK2JAK1TYK2JAK3 | |
| SCHEMBL9255359 | 0.88 | PTGER4 (0.49) | PTGER4JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |