Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.49 |
| ▸ | BCHE | P06276 | 3/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9258648 | 0.92 | ACHE (0.46) | ACHEBCHEMAOAMAOBHTR2A | |
| SCHEMBL9260426 | 0.88 | ACHE (0.54) | ACHEBCHEMAOAMAOB | |
| SCHEMBL9260674 | 0.86 | ACHE (0.53) | ACHEBCHEMAOAMAOB | |
| SCHEMBL9255390 | 0.85 | BCHE (0.43) | ACHEBCHEMAOBHTR2A | |
| SCHEMBL9259960 | 0.80 | BCHE (0.48) | ACHEBCHEMAOAMAOB | |
| SCHEMBL9264044 | 0.80 | ACHE (0.51) | ACHEBCHEMAOAMAOB | |
| SCHEMBL9264663 | 0.77 | BCHE (0.53) | ACHEBCHEMAOAMAOB | |
| SCHEMBL9255264 | 0.76 | BCHE (0.50) | ACHEBCHEMAOB | |
| SCHEMBL9261356 | 0.76 | ACHE (0.55) | ACHEBCHEMAOBHTR2A | |
| SCHEMBL9260604 | 0.74 | ACHE (0.56) | ACHEBCHEMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | claimed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | claimed |
| US-5428043-A | Tricyclic-cyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |