Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BAX | Q07812 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252305 | 0.87 | SOAT1 (0.47) | SOAT1LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL9259222 | 0.82 | SOAT1 (0.47) | SOAT1LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL9260748 | 0.76 | PPARG (0.39) | SOAT1TSHRHDAC1HDAC6HDAC3 | |
| SCHEMBL9259382 | 0.73 | SOAT1 (0.47) | SOAT1LPAR1LPAR5TSHRHDAC1 | |
| SCHEMBL9256781 | 0.73 | HDAC1 (0.50) | SOAT1LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL9784466 | 0.72 | SOAT1 (0.68) | SOAT1 | |
| SCHEMBL9577823 | 0.72 | SOAT1 (0.43) | SOAT1LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL9256182 | 0.72 | SOAT1 (0.43) | SOAT1LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL9260476 | 0.70 | HDAC3 (0.39) | LPAR1LPAR5HDAC1HDAC6HDAC3 | |
| SCHEMBL9252064 | 0.70 | SOAT1 (0.42) | SOAT1LPAR1LPAR5HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5422373-A | An alkoxybenzyl-alkylene-arylurea anticholesterol, antilipemic agents and enzyme inhibitors | BURROUGHS WELLCOME CO. (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0550568-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006075-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |