Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 2/20 | 0.58 |
| ▸ | TACR2 | P21452 | 14/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828888 | 0.94 | TACR2 (0.66) | TACR2TACR1 | |
| Citric Acid SCHEMBL8940484 | 0.91 | TACR2 (0.58) | TACR2TACR1 | |
| Citric Acid SCHEMBL8940494 | 0.91 | TACR2 (0.58) | TACR2TACR1 | |
| Citric Acid SCHEMBL8940427 | 0.91 | TACR2 (0.59) | TACR2TACR1 | |
| Citric Acid SCHEMBL9050091 | 0.90 | TACR2 (0.61) | TACR2TACR1 | |
| SCHEMBL8829018 | 0.84 | TACR2 (0.64) | TACR2TACR1 | |
| SCHEMBL8828883 | 0.84 | TACR2 (0.64) | TACR2TACR1 | |
| Citric Acid SCHEMBL8940410 | 0.84 | TACR2 (0.60) | TACR2TACR1 | |
| Citric Acid SCHEMBL8940339 | 0.84 | TACR2 (0.60) | TACR2TACR1 | |
| Citric Acid SCHEMBL8940461 | 0.83 | TACR2 (0.62) | TACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995012577-A1 | NOVEL 4-PIPERIDINYL SUBSTITUTED LACTAMES AS NEUROKININ 2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ASTHMA | ZENECA LIMITED (GB) | 1995-05-11 | — | — | WO | disclosed |