SCHEMBL9255680

SCHEMBL9255680

CCCN(Cc1ccc(-c2ccccc2C(=O)c2nnn[nH]2)cc1)c1ncccc1C(=O)O

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 20/20 0.67
AGTR2 P50052 20/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9256905 0.90 AGTR1 (0.59) AGTR1AGTR2
SCHEMBL7048946 0.88 AGTR1 (0.72) AGTR1AGTR2
SCHEMBL9589710 0.87 AGTR1 (0.71) AGTR1AGTR2
Potassium SCHEMBL9589729 0.87 AGTR1 (0.71) AGTR1AGTR2
SCHEMBL9589609 0.82 AGTR1 (0.73) AGTR1AGTR2
SCHEMBL8569237 0.82 AGTR1 (0.69) AGTR1AGTR2
Methylamine SCHEMBL9590818 0.81 AGTR1 (0.71) AGTR1AGTR2
SCHEMBL29486793 0.80 AGTR1 (1.00) AGTR1AGTR2
SCHEMBL9590003 0.80 AGTR1 (0.72) AGTR1AGTR2
SCHEMBL29392041 0.80 AGTR1 (1.00) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5459148-A Cardiovascular disorders SANKYO COMPANY, LIMITED (JP) 1995-10-17 US disclosed
EP-0603001-A1 Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease SANKYO COMPANY LIMITED (JP) 1994-06-22 EP disclosed