Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9255736 | 1.00 | PROKR1 (0.34) | PROKR1FPR2HTR2AHTR2CMAOB | |
| SCHEMBL9255744 | 1.00 | PROKR1 (0.34) | PROKR1FPR2HTR2AHTR2CMAOB | |
| SCHEMBL9246826 | 0.90 | PROKR1 (0.34) | PROKR1FPR2HTR2AHTR2CMAOB | |
| SCHEMBL9246820 | 0.90 | PROKR1 (0.34) | PROKR1FPR2HTR2AHTR2CMAOB | |
| SCHEMBL9246812 | 0.90 | PROKR1 (0.34) | PROKR1FPR2HTR2AHTR2CMAOB | |
| SCHEMBL9481182 | 0.88 | SLC6A2 (0.35) | MAOBMAOASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9481211 | 0.88 | SLC6A2 (0.35) | MAOBMAOASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9481205 | 0.88 | SLC6A2 (0.35) | MAOBMAOASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9262567 | 0.88 | PNMT (0.39) | PNMTTAAR1SIGMAR1 | |
| SCHEMBL9262557 | 0.88 | PNMT (0.39) | PNMTTAAR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458176-B1 | Bicyclohexyl derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | EP | disclosed |
| US-5174921-A | BICYCLOHEXYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1992-12-29 | — | — | US | disclosed |
| EP-0458176-A1 | Bicyclohexyl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-11-27 | — | — | EP | disclosed |