Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9256202 | 0.89 | JAK2 (0.55) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9253691 | 0.87 | JAK2 (0.60) | JAK2JAK1TYK2JAK3PTGER4 | |
| Hydrochloric Acid SCHEMBL9254291 | 0.86 | JAK2 (0.59) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9255820 | 0.86 | ADORA2A (0.54) | JAK2JAK1TYK2JAK3PTGER4 | |
| Hydrochloric Acid SCHEMBL9251811 | 0.86 | HDAC1 (0.50) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL8863519 | 0.85 | HDAC1 (0.52) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| SCHEMBL9250822 | 0.85 | ADORA2A (0.46) | JAK2JAK1TYK2JAK3TRPA1 | |
| SCHEMBL9247566 | 0.85 | PTGER4 (0.49) | JAK2JAK1TYK2JAK3PTGER4 | |
| Hydrochloric Acid SCHEMBL9255053 | 0.85 | HDAC1 (0.51) | HDAC1HDAC8HDAC6HDAC3HDAC2 | |
| Hydrochloric Acid SCHEMBL9252320 | 0.85 | HDAC1 (0.51) | HDAC1HDAC8HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |