Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9249665 | 0.85 | TMPRSS15 (0.42) | ADORA2A | |
| SCHEMBL9255968 | 0.85 | HDAC1 (0.51) | ADORA2AEGLN1EGLN2TRPA1JAK2 | |
| SCHEMBL9256202 | 0.78 | JAK2 (0.55) | ADORA2ATRPA1JAK2JAK1TYK2 | |
| SCHEMBL9252129 | 0.77 | IRAK4 (0.41) | ADORA2AIRAK4EGLN1EGLN2TRPA1 | |
| SCHEMBL9248776 | 0.76 | NAMPT (0.41) | EGLN1EGLN2 | |
| SCHEMBL9253691 | 0.76 | JAK2 (0.60) | ADORA2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL9255820 | 0.76 | ADORA2A (0.54) | ADORA2AJAK2JAK1TYK2JAK3 | |
| Hydrochloric Acid SCHEMBL9254291 | 0.76 | JAK2 (0.59) | ADORA2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL9252486 | 0.76 | ITGB3 (0.43) | — | |
| Bromide SCHEMBL9254604 | 0.75 | ITGB3 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |