SCHEMBL9256348

SCHEMBL9256348

CCOC(=O)Cn1nnnc1-c1cnc2cccc(C)n2c1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.46
CYP2C19 P33261 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
KDM4E B2RXH2 3/20 0.39
GAA P10253 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
ALDH1A1 P00352 3/20 0.38
HTT P42858 2/20 0.37
HSD17B10 Q99714 2/20 0.36
PKM P14618 1/20 0.36
ATM Q13315 1/20 0.36
MAPT P10636 1/20 0.36
TSHR P16473 1/20 0.35
CA12 O43570 1/20 0.35
CA2 P00918 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9263856 0.84 HTT (0.38) CYP2C19CYP1A2CYP2C9KDM4EMEN1
SCHEMBL9276524 0.83 MAPK1 (0.46) MAPK1CYP2C19CYP1A2CYP3A4CYP2C9
SCHEMBL9255169 0.82 CYP1A2 (0.43) CYP2C19CYP1A2CYP2C9L3MBTL1SMN1; SMN2
SCHEMBL9259026 0.80 ADORA2A (0.38) CYP2C19CYP1A2CYP2C9MEN1KMT2A
SCHEMBL9263794 0.76 HTT (0.40) CYP2C19CYP1A2CYP3A4SMN1; SMN2KDM4E
SCHEMBL9256929 0.73 MAP3K5 (0.39) CYP2C19CYP1A2HTTMAPT
SCHEMBL11248747 0.71 KDM4E (0.60) MAPK1CYP2C19CYP1A2L3MBTL1SMN1; SMN2
SCHEMBL8947294 0.71 MAPK1 (0.61) MAPK1CYP2C19CYP1A2CYP3A4CYP2C9
SCHEMBL8843434 0.69 HTT (0.57) MAPK1CYP2C19CYP1A2CYP3A4CYP2C9
SCHEMBL9256353 0.69 KDM4E (0.36) MAPK1KDM4EGAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5475000-A Antiulcer agents CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1995-12-12 US disclosed