Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 14/20 | 0.73 |
| ▸ | CYP19A1 | P11511 | 11/20 | 0.73 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.73 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27971316 | 0.92 | CYP19A1 (0.71) | CYP11B2CYP19A1CYP11B1KCNH2CYP17A1 | |
| SCHEMBL9261654 | 0.92 | CYP19A1 (0.71) | CYP11B2CYP19A1CYP11B1KCNH2CYP17A1 | |
| Dexfadrostat SCHEMBL685516 | 0.84 | CYP19A1 (1.00) | CYP11B2CYP19A1CYP11B1KCNH2 | |
| Fadrozole SCHEMBL3295820 | 0.84 | CYP19A1 (1.00) | CYP11B2CYP19A1CYP11B1KCNH2 | |
| Fadrozole SCHEMBL25491 | 0.84 | CYP19A1 (1.00) | CYP11B2CYP19A1CYP11B1KCNH2 | |
| S-Fadrozole SCHEMBL13449014 | 0.84 | CYP19A1 (1.00) | CYP11B2CYP19A1CYP11B1KCNH2 | |
| Fadrozole SCHEMBL4143 | 0.83 | CYP19A1 (1.00) | CYP11B2CYP19A1CYP11B1KCNH2 | |
| Dexfadrostat SCHEMBL4619633 | 0.83 | CYP19A1 (1.00) | CYP11B2CYP19A1CYP11B1KCNH2 | |
| Fadrozole SCHEMBL9739941 | 0.83 | CYP19A1 (1.00) | CYP11B2CYP19A1CYP11B1KCNH2 | |
| Fadrozole SCHEMBL122801 | 0.83 | CYP19A1 (1.00) | CYP11B2CYP19A1CYP11B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428160-A | Condensation of imidazole derivative with cyano- or halo-substituted benzene derivative containing leaving group esterified with carboxylic or sulfonic acid | CIBA-GEIGY CORPORATION (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0165904-B1 | SUBSTITUTED BICYCLE COMPOUNDS | CIBA-GEIGY AG (CH) | 1991-04-10 | — | — | EP | disclosed |
| US-4889861-A | Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors | CIBA-GEIGY CORP. (US) | 1989-12-26 | — | — | US | disclosed |
| US-4728645-A | THROMBOXANE SYNTHETASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0165904-A2 | Substituted bicycle compounds | CIBA-GEIGY AG (CH) | 1985-12-27 | — | — | EP | disclosed |