Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.58 |
| ▸ | IDH1 | O75874 | 7/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | F11 | P03951 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691248 | 0.87 | DAO (0.58) | DAOIDH1GPR35F11 | |
| SCHEMBL20557391 | 0.80 | CHEK1 (0.47) | IDH1CHEK1MCL1ALDH1A1KDM4E | |
| SCHEMBL1903750 | 0.77 | BRD4 (0.55) | DAOIDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29890500 | 0.77 | BRD4 (0.55) | DAOIDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL28323935 | 0.77 | PSMB8 (0.51) | DAOIDH1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL16695793 | 0.76 | IDH1 (0.59) | IDH1MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL10686493 | 0.76 | MCL1 (0.40) | DAOIDH1MCL1ALDH1A1KDM4E | |
| SCHEMBL10692921 | 0.75 | KDM4E (0.45) | IDH1MEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL16767847 | 0.74 | DAO (1.00) | DAOGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2463866 | 0.74 | DAO (0.64) | DAOIDH1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5475008-A | Selective non-competitive antagonists of n-methyl-d-aspartate receptors | MERCK SHARP & DOHME LIMITED (GB) | 1995-12-12 | — | — | US | disclosed |
| EP-0614363-A1 | QUINOLONE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1994-09-14 | — | — | EP | disclosed |
| WO-1993010783-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS AMPA AND NMDA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |