Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.40 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252048 | 0.86 | AGTR1 (0.41) | AGTR1LTB4R2AGTR2 | |
| SCHEMBL9541024 | 0.85 | AGTR1 (0.47) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL9257314 | 0.83 | AGTR1 (0.40) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL9248296 | 0.83 | AGTR1 (0.48) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL9671801 | 0.77 | AGTR1 (0.64) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL9672263 | 0.76 | AGTR1 (0.51) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL683434 | 0.76 | AGTR1 (0.66) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL8702000 | 0.75 | AGTR1 (0.47) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL8958378 | 0.75 | AGTR1 (0.54) | AGTR1LTB4R2AGTR2ABCC3ABCC4 | |
| SCHEMBL8958364 | 0.75 | AGTR1 (0.54) | AGTR1LTB4R2AGTR2ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599999-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLINONE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-06-08 | — | — | EP | claimed |
| US-5424450-A | Angiotensin II receptor blocking imidazolinone derivatives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1995-06-13 | — | — | US | disclosed |
| EP-0599999-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLINONE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-06-08 | — | — | EP | disclosed |